What is the value of an original 1965 operation board game in MISB?

I do not have access to real-time information, including pricing data for collectible items. The value of an original 1965 Operation board game in MISB (Mint In Sealed Box) condition can vary greatly depending on a number of factors, including:

* Condition: The condition of the box, game pieces, and instructions will significantly impact the value. A pristine, unplayed set in a sealed, undamaged box will be worth significantly more than a set with wear and tear.

* Rarity: The specific edition and variations of the game can also affect its value. For example, early editions or special versions may be more sought after.

* Demand: The current market demand for this specific item will also play a role in determining its value.

* Seller and Buyer: The price can vary depending on the individual seller and buyer and the platform where the item is being sold.

To find the approximate value of your specific Operation game:

1. Check online auction websites: Sites like eBay, Catawiki, and others will have sold listings for similar games. This can give you an idea of current market prices.

2. Consult collector's guides and price guides: There are specialized books and websites dedicated to vintage games that can provide information on values.

3. Visit specialized forums and communities: Online forums dedicated to board games and collectibles often have knowledgeable members who can provide insights on specific game values.

Remember, these are just estimates. The actual value of your game will be determined by the specific factors mentioned above and the individual buyer. It is always recommended to get professional appraisals from experienced collectors or auction houses for a more accurate valuation.