Can you use a PS4 controller on tdu2?

Unfortunately, you cannot use a PS4 controller on TDU2.

TDU2 was released in 2009 for PC, Xbox 360, and PlayStation 3. It was not designed to be compatible with controllers from later generations of consoles.

You can use a PlayStation 3 controller on a PC to play TDU2, but you'll need to connect it via a wired connection, and may need to install some third-party software to make it work.