Pet Supply Hunting
Make a list of pet supplies for your guests to track down, for example, a well-chewed tennis ball, a litter scoop (preferably clean), two sunflower seeds, a Frisbee, one dog biscuit or cat treat, a birdcage mirror and a leash. Make things interesting by limiting the search to your neighborhood (with your neighbors' cooperation) or allow the searchers to look anywhere, including pet-supply stores.
Big 'Game' Hunting
You don't have to go on a safari to plan this one. All you need is a list of board games and a particular piece from each one. For example, an "E" from a Scrabble game, a boot from a Monopoly game and a pink wedge from a Trivial Pursuit game. Throw in a card or two from Old Maid and Uno, a timer, one jack and one marble. Limit the search to one neighborhood, several blocks or the whole town. Make it a virtual scavenger search and accept emailed lists of sites where the participants found the items.
People Hunting
Things can get interesting when people are both the hunter and the hunted. If you're holding a scavenger hunt for family members and friends, put some of them on the list. Rather than specifying a particular individual, use a generic description such as "one aunt" or "one college roommate." This type of hunt will work well for a city-sponsored event or charity fundraiser, as long as it's well-publicized beforehand so that the hunted people know what's going on. Expand your scavenger list to include a doctor, a fireman, a store clerk and so on. Rather than having the hunters drag their prey along with them, or risk losing a "catch" due to mistrust or time constraints, have the hunters give each found person a ticket to appear at a central location to check in.