Blood
Mammals are classified by their warm-blooded nature. Mammals are able to maintain a constant body temperature utilizing their skin, hair and fur to help regulate their temperature. Amphibians are ectothermic, which means they have cold blood. They are only able to achieve body heat from the outside environment. The body temperature of amphibians is the same as that of the air or water around them.
Respiration
Mammals require the intake of oxygen in order to breathe. Some amphibians are able to breathe under water, and others breathe air like mammals do. For young larvae born in water, they develop gills and are able to breathe under the water. Meanwhile the adults of this same animal classification exist on land and breathe through skins and lungs.
Reproduction
Mammals reproduce sexually. The female has eggs that are fertilized internally by the male. Amphibians also reproduce sexually, however the eggs of amphibians are fertilized outside of the mother's body. Mammals give birth to live offspring after a period of gestation. Females then produce milk that is used to feed their offspring. Amphibians lay eggs in the water when they give birth. The early life of these offspring is spent under the water, breathing through gills.
Food
Mammals are omnivores; meaning they consume both plant life and meat of other creatures for sustenance. Amphibians are overwhelmingly carnivores. Water amphibians eat small reptiles, fish and crustaceans. Land amphibians eat insects and worms.
Physical Appearance
Mammals have four limbs and ears that protrude. Amphibians have webbed feet; moist, smooth skin; and can have between zero and four limbs.