History
By A.D. 150 there were 48 recognized constellations named and classified by the Greeks, with Cancer among them.
Significance
The constellation has an association with the Hercules legend, representing the crab that attacked the hero as he fought the Hydra in one his Twelve Labors. After Hercules crushed it, the goddess Hera (no fan of Hercules) rewarded its brave effort by placing it in the sky as a constellation.
Considerations
Cancer contains no bright stars but does have an interesting area within its borders, an open cluster of stars that Galileo saw fit to study with his telescope.
Praesepe
This open cluster has the name Praesepe, a Latin word that means crib, manger or hive. In modern times, the English began to refer to this cluster as the "Beehive" for its many stars resembling swarming bees.
Fun Fact
Two of the brighter stars within Cancer are Acubens, which translates into "claw," and Al Tarf, which is Arabic for "the end" and marks the back legs of the crab.