Slope
A young river cutting into an uplifted landscape or a head-water stream draining mountainous country experiences high gradient in its flow because of the severe slopes of its watershed. That gradient grants the watercourse down-cutting power, resulting in significant rates of erosion. By contrast, a big, mature river in level country begins to meander across a broad floodplain, depositing sediments along point bars and during inundations of its low-lying surroundings.
Uplift
Even a mature stream winding its way sluggishly across a flat floodplain can find itself rejuvenated, as geologists say, with a change of sea level. This could come in the form of an ice age, when the increase of continental and alpine glaciers and ice-sheets locks up more water in frozen form, lowering the level of the oceans. More commonly, tectonic activity -- a collision of tectonic plates, for example, or severe faulting -- raises some block of land, resulting in renewed down cutting on the part of the river. Uplift of the floodplain of a mature river might produce a deep, precipitous gorge, rendering the floodplain into an inundation-free terrace above the lip of the gorge. Entrenched meanders exist in spectacular form on the Colorado Plateau of the southwestern U.S., may stem from a relatively slow, measured uplift, where a mature river has the ability to erode while maintaining its meanders.
Bedrock
Through its course, a river often flows over different layers of bedrock, the contrasting resistance of which can affect its gradient. A down-cutting river building a broad valley might encounter a buried belt of durable rock that erodes more slowly than surrounding layers. In such a case, a waterfall may result as points downstream of the resilient bedrock are eroded more quickly, and the hard layer is undercut.
Other Influences
Biological phenomena may exert an influence on a river gradient. One example is the industrious activity of one of the world's largest rodents, the beaver, which inhabits wetlands of the Northern Hemisphere. Beavers will dam a fast-moving creek or river with felled logs, mud and other materials to create a backwater with the depth and dimensions amenable to their foraging and shelter. Where once a mountain stream tumbled through rapids, a low-gradient swamp or small lake now stands; over time, if the beavers move on, the body of water may gradually fill in to form a meadow or shrub land.