Walls
Four-pieces (or fours) can be stacked high and wide for walls of castles, houses, forts and rocket gantries. A good rule of thumb is to avoid using any fours side by side or connected straight up. Zigzag the fours just like a brick wall. Also, fours can be used as spacers between larger pieces, to keep the construction interlocked and sturdy.
Corners
Using fours to make a corner seems tricky but is easy once you start. One idea is to connect one peg to one hole to a block on top. Repeating this process will make an assembly that can be curved or bent to a desired angle. Just be careful until the entire assembly is completed: Attaching Lego pieces by just one peg can make them easily fall apart. Once the corner is complete, attach it to an existing vertical wall. This will reinforce and stabilize the corner section.
Towers
Fours can be stacked to the ceiling with various sizes. Start with a base of the number of fours for the tower's four walls. Add each additional row, and continue until you reach the desired height. For the corners, consider using twos (two-pegged rectangular pieces) and ones to secure around the right-angle, and then continue adding fours to the sides.
Rails
Fours are great for making rails for trains or especially monorails. Just make a track of four, two rows high, for the length of the track. Then turn the rail over. This makes a smooth running surface for the vehicle. Building a futuristic monorail may take other size pieces, but a slot on the bottom the width of the fours will ride on the track effortlessly.
Fours with Other Lego pieces
Always have plenty of fours when building any Lego construction. They come in handy when fashioning a window or door opening in a building or making a small addition to a car, airplane or rocket ship. Stacking fours make great pillars and posts. Pyramids of fours can be used as foundations or pointed roof tops on towers and small buildings.