Instructions
Uninstall and then reinstall the game. "San Andreas" may not have loaded properly on your initial install and several files may have been corrupted, which leads to crashes.
Click the "Start" button then type "msconfig" into the search bar followed by the "Enter" key to bring up the Systems Configuration Utility. Navigate to the "Selective Startup" menu under the "General" tab. Uncheck the "Load Startup Items" box. Check the "Hide All Microsoft Services" and "Disable All" boxes under the "Services" tab. Click "Ok" and restart your PC. The PC will start up with no background programs that may interfere with the game. Proceed to Step 3 if the game still crashes.
Right-click on the game's primary icon (not the shortcut icon) and select "Properties." Select the "Compatibility" tab and then check "Run This Program in Compatibility Mode For" then select "Windows 98/Windows ME." This will tune down the game's graphics so that your PC can handle it. The game may be crashing because it features graphics that are too advanced for your particular computer to render.
Update the graphics card drivers. The graphics card on your PC is what handles the 3D rendering in games. Your card's software may be out of date. Look up your card and download the latest drivers from the manufacturer's website.
Run a malware removal tool to clean your computer of spyware or other viruses. These programs may be interfering with the game, which is what causes it to overload the CPU and crash.
Download the latest version of DirectX 9 from Microsoft. DirectX 9 is a packet of information that helps control graphics processing on your computer. The game may crash if the latest version is not installed.