Instructions
Blast a few of the Spatters with Paint. This will turn them into your allies, and they will start attacking enemies. Since they are fairly weak creatures, they are likely to die, particularly if they are fighting anything other than Spatters.
Place a TV Sketch down in front of Spatters, if you are getting overwhelmed by a large group of them. This will distract them while you get ready to attack them.
Blast the Spatters with Thinner. This is the easiest way to get rid of them, though you can use Mickey's Spin Attack to defeat them, too.
Lure the Spatters toward groups of Bunny Children, if you happen to be in a level where you encounter such groups. Once the Spatters are in range, the Bunny Children will eat them.