Instructions
Equip your most powerful weapon, such as an upgraded magnum like the L. Hawk or S&W M29.
Run over to the door on the right side of the room and examine it. The door is locked, but Wesker will kick you through it.
Run into the series of winding corridors and turn a corner to escape Wesker's line of sight. Wesker will say things like "You can't hide forever" when he cannot see you.
Wait behind a corner where he cannot see you and position yourself so you can see around the corner. Wait for Wesker to come into view.
Move out from around the corner and quickly shoot him before he has a chance to react. You will be able to hit him two to three times before he dodges your shots.
Turn around and run further into the corridor to get away from Wesker and break his line of sight. Wait at the next corner and repeat this process until Wesker falls to his knees to earn the trophy.