Things You'll Need
Instructions
Use your first safehouse, the Barracks, as often as you can. You will lose this safehouse after the third mission, so you should get what you can from it early on.
Acquire your second safehouse by completing the mission entitled "Conduct Unbecoming." Your new safehouse will be called 101 Bayshore Avenue; there is a garage in the alley behind it where you can save a car if you desire.
Find your third safehouse, called "The Compound," by completing the mission entitled "From Zero to Hero." This is an upgraded safehouse with more garages for newer cars. Note that you will keep 101 Bayshore Avenue when you acquire this safehouse.
You can get the final safehouse, the Clymenus Suite, after completing the mission "White Lies." Like the other two safehouses, this one does not replace earlier safehouses.
If you choose to do the Empire-building missions, any new businesses you create will also serve as smaller versions of your main safehouses. However, you will not be able to replenish your weapons at the businesses.