Instructions
Power off the PlayStation 2 and remove the memory card from the memory card slot.
Examine the memory card slot for any obstructions and carefully check the memory card for anything that may be inhibiting the connection to the console, such as dust, dirt or grime. Use a can of compressed air to clean the memory card connectors and the memory card slot if there's an excessive amount of dust, spraying in short bursts.
Slide the memory card into the memory card slot, pushing firmly to make sure it's connected completely.
Power on the PlayStation 2 with the disc tray open.
Select "Browser" and choose the memory card from the browser menu.
Compare the amount of free space on the memory card to the space requirements printed on the back of the game box. If there's not enough space to save a game, it won't be able to save. Delete a file to clear up space by selecting it with the "X" button and choosing the "Delete" option.
Start the game and try saving, paying attention to the on-screen instructions during the save prompt. Certain games instruct you to keep the memory card in a specific port in order to save. This varies from title to title.