Instructions
Extract the ISO file, if necessary. You must extract files that are in RAR, 7Z or ZIP format. Right-click the file and select "Open" or "Extract."
Launch ePSXe and click on "File" at the top of the window. Click "Run ISO." The "Open" window appears.
Locate the ISO you want to load. Double-click it to load it. The game may not start immediately. Wait for a minute for the emulator to "read" the ISO.