Instructions
Unplug the Saitek x45 from your computer.
Click the "Start" menu on the Windows task bar and open the "Run" menu.
Type "Regedit" into the "Run" box when it appears, then press "Enter." This will launch the Windows Registry Editor.
Browse to the following registry key:
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\MediaProperties\PrivateProperties\DirectInput
Select and delete the "VID_06A3&PID_053C" and/or "VID_06A3&PID_2541" folder(s). These folders contain the calibration data for your Saitek X45. Removing them will delete the calibration configuration for your joystick.