Instructions
Insert the "Duke Nuken 3D" disc into the Xbox 360 or download the game directly from Xbox Live.
Wait for the game to load.
Direct your controller to the "Settings" option on the game's "Start" menu.
Select the "Settings" option and then select "Controller Options."
Adjust the buttons to a setting that you are comfortable with. You can change the trigger and toggle buttons, the arrow buttons and the number buttons to work as you desire.
Save your settings by selecting "Save."