Hand-to-Hand Weapons
Hand-to-hand weapons are used in close combat to quickly eliminate foes without using ammunition. Certain types of enemies tend to favor some weapons over others. The baseball bat is quick and highly damaging, and it can be found on rival gangsters. The nightstick can be obtained from dispatched cops, although it is slow and lacks power. The crowbar is commonly used by pimps and, while slower than the baseball bat, is very powerful. The knife is found on rival gangsters and is quick and damaging, but it lacks reach.
Handguns
Handguns are good for attacking quickly at long distances. The Vice 9 is the cheapest gun you can purchase at the gun store, but it lacks firepower. The NR4 is more powerful than the Vice 9 and is found on some gangsters and cops. The .44 Shepard is a powerful revolver that can dispatch enemies with one shot, but it has low ammunition capacity. The .50 GDHC is similar to the .44 Shepard, is slightly less powerful and holds more ammunition. The Gold-Plated .50 GDHC is very powerful and must be unlocked by completing the Carnales Hitman side quest.
Shotguns
Shotguns are good for dispatching several enemies at once within close range of each other. The Tombstone is used by police and features an eight-round magazine. The 12 Gauge has a six-round magazine and is more powerful than the Tombstone. The AS12 Riot has the fastest rate of fire of all the shotguns, but has the shortest range. The Platinum AS12 Riot is similar to the AS12 Riot but holds twice as much ammunition and is more powerful. The Pimp Cane Shotgun is the most powerful shotgun in the game; it must be unlocked by completing the Snatch Activities.
Submachine Guns
Submachine guns are rapid-fire and useful for dispatching large groups of foes and vehicles. The T3K Urban is the cheapest submachine gun, with moderate fire power. The SKR 7 Spree is more powerful and holds more ammunition than the T3K Urban, but is more expensive. The Platinum T3K is the most powerful submachine gun in the game; it is obtained by completing the Snatch Activities.
Rifles
Rifles are good for shooting accurately from very long distances because of their ability to zoom in. The K6 Krukov is an automatic weapon that can be used as a hand-to-hand weapon and holds 30 shots. The McManus is very powerful, but only holds five shots and cannot be used as a hand-to-hand weapons. The AR-40 Xtnd is the most powerful rifle in the game; it can only be obtained from SWAT members.
Explosives
Explosives are one-time-use weapons good for clearing out large crowds of enemies and taking out large vehicles. Pipe bombs are the cheapest explosives, but are slow to explode. Molotov cocktails explode and set fire to their targets. Molotov cocktails should be used at a long range because their fire is damaging if you get too close. Hand grenades are similar to pipe bombs, but explode faster and are more powerful. The RPG launcher fires explosives over long distances and is best-suited for taking out vehicles. The Platinum RPG launcher holds twice as much ammunition as the RPG launcher; it must be unlocked by dispatching all the hitman targets.