Instructions
Play through the first level until you begin your initial battle with the Lizard. Jump to the safe end of one of the conveyer belts and press "LB" to activate your reflex mechanism.
Press "A" rapidly once the Lizard jumps out of water and tackles you. This will slam the Lizard into the conveyer grinder. Repeat this for all three grinders and the Lizard will be stunned. Approach him and press "Y" to initiate a button sequence to finish him off for this round.
Press the buttons as they appear on the screen until you throw the Lizard into the next room. Use the "LB" button to dodge most of his attacks, and counter-attack whenever possible to drain his health. Jump back whenever a red glowing ring appears around the Lizard's hands to avoid his attack.
Attack the Lizard until his health bar drops to half full, which will give him the red glowing ring for the rest of the battle. Jump back whenever you see a purple icon over his head, and continue attacking until you've drained his health. Follow the button sequence to defeat the Lizard the first time.
Continue playing the level until you've defeated Kraven and have begun another fight with the Lizard. Avoid his acid roar by staying away from him, then press "LB" to avoid his charge attack. Finally, use "LB" and stay far enough away to avoid his acid splatter attack. Press "B" once these attacks are finished to shoot webbing onto his hands.
Jump towards the Lizard and press "X" while he is trying to remove the webbing from his hands. Press "B" when the "B" icon appears above his tail, and rotate the left joystick to throw him into the generators. Release the Lizard by pressing "B" again. Throw him into all four generators to move onto the next stage of the fight.
Avoid the Lizard's jumping attack by pressing "LB" just before he leaps from the wall onto the ground. Approach the Lizard after he is stuck into the ground and attack him until he gets free again. Continue using this method to drain his health until a "Y" icon appears near him. Press "Y" and follow the buttons shown to finally defeat the Lizard.